By Nozomu Mori, Inhee Mook-Jung
This e-book brings jointly the main updated info on contemporary examine result of best laboratories on getting older technological know-how in East Asia, quite in Japan, Korea, and Hong Kong. beginning with a finished evaluate of varied hypotheses on organic mechanisms of getting older by way of Dr. Sataro Goto, every one bankruptcy covers wide points of the latest findings in aging-related subject matters: centenarian experiences and genome research of progeria, metabolic biochemistry and neurobiology, sturdiness controls in yeast and nematodes, oxidative tension and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with extra power healing techniques to those age-related neurodegenerative illnesses. additionally integrated, partially, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older center for toughness (AACL) that has been held every year alternating among Japan and Korea over the last decade. This e-book can function an invaluable source for locating acceptable collaborators within the parts it covers. the objective readership is made of graduate scholars and researchers at universities, scientific and/or life-science faculties, and biomedical and pharmaceutical institutes.
Why does getting older exist? How can we age? How is every one organism’s lifespan decided? those are primary questions within the box. We might be nonetheless faraway from attaining a whole view of getting older mechanisms, yet this booklet, Aging Mechanisms, deals a great chance to get to grips with the main up to date growth within the biomedical examine of getting older in Japan and Korea, the 2 major international locations for human longevity.
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Extra info for Aging Mechanisms: Longevity, Metabolism, and Brain Aging
1995). For example, it was demonstrated that the half-lives of enolase in nematodes and aldolase in mice are extended in old animals compared with their younger counterparts, as determined by pulsechase experiments. We found that the half-life of the various proteins introduced into mouse hepatocytes in primary culture were extended by 40–60 % in the cells from old animals (Goto et al. 2001; Ishigami and Goto 1990). It was also shown that prematurely terminated puromycinyl peptides, as a model of altered proteins, are much more slowly degraded in the livers of old mice than in those of younger animals (Lavie et al.
The autophagy-lysosome system is considered to act via microautophagy, macroautophagy and chaperon-mediated autophagy, and the latter two systems are the predominant mechanisms of autophagy in animals. Macroautophagy refers to the digestion of contents of cytoplasmic regions engulfed in membrane vesicles, which then fuse with lysosomes for degradation. Chaperon-mediated autophagy is the digestion of substrates bound to the chaperon heat-shock cognate protein (hsc70), which is recognized by lysosomes via an interaction with the receptor protein on the surface.
During the recent two decades, the number of centenarian studies has appreciably increased, expanding our knowledge of biomedical and genetic underpinnings as well as psychosocial correlates of healthy longevity. In the first part of this review, we summarize functional and biomedical characteristics of centenarians mainly based on the results from the Tokyo Centenarian Study (TCS), an interdisciplinary research on the oldest old. We propose several hypotheses on human aging based on these findings.