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By Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter Riederer, Prof. Dr. Moussa B. H. Youdim (eds.)

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Extra info for Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990

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2, lane 4) was higher than that in the brain (Fig. 2, lane 2) may indicate that the 3' ends may be different in the brain and placenta. The tissue specificity of MAO-A and B gene expression has been demonstrated and may provide insight into their physiological roles. Acknowledgements This work was supported by grants R37 MH 39085 (Merit Award) and Research Scientist Award K05 MH 00796 from NIMH, DHHS. The support from Boyd and Elsie Weline professorship are also greatly appreciated. References Bach AWl, Lan NC, 10hnson DL, Abell CW, Bembenek ME, Kwan S-W, Seeburg PH, Shih lC (1988) cDNA cloning of human monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

Imaging striatal dopaminergic neurons Because catecholamines do not penetrate the blood-brain barrier, replacement of dopamine which is deficient in brain of patients with Parkinson's disease requires use of L-DOPA, the amino acid precursor of this neurotransmitter. L-DOPA, usually administered with a peripheral decarboxylase inhibitor, is transported across the blood-brain barrier and is decarboxylated to form dopamine. As indicated above, the decarboxylase is not specific and will decarboxylate a variety of amino acids, including analogues of L-DOPA such as 5- or 6-fluorodopa.

Raven Press, New York, pp 513-526 36 M. Ackenheil Mogilnicka E, Boissard CG, Waldmeier PC, Delini-Stula A (1983) The effects of single and repeated doses of maprotiline, oxaprotiline and its enantiomers on foot-shock induced fighting in rats. Pharmacol Biochem Behav 19:719-723 Mogilnicka E, Zazula M, Wedzony K (1987) Functional supersensitivity to thect 1 adrenoceptor agonist after repeated treatment with antidepressant drugs is not conditioned by fj-down-regulation. Neuropharmacology 26(10): 1457-1461 Morgan n, Curran T (1989) Stimulus-transcription coupling in neurons: role of cellular immediate-early genes.

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