By Marek Michalak Ph.D. (auth.)
This e-book is set calreticulin, a multifunctional calcium binding protein first stumbled on over two decades in the past. The protein has been defined in a variety of destinations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, mobilephone floor or even secreted into the blood movement. This quantity outlines the newly chanced on features for calreticulin together with its keep an eye on of calcium homeostasis, modulation of steroid-sensitive gene expression, regulate of viral RNA replication, modulation of nuclear delivery, position in T lymphocyte activation and cytotoxic killing, chaperone functionality, keep watch over of adhesion-dependent signaling through integrins, attainable position within the biology of ticks, within the pathology of autoimmune illnesses and in blood function.
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Extra info for Calreticulin
3' Hopefully, in the near future, we will have a better understanding of the functional consequences of Ca2 + binding (and/or other cation) to calreticulin. It would be fascinating to understand a role for the unique high affinity Ca2 + binding site in the protein. ACKNOWLEDGMENT We are grateful to Thidi (Dr. M. Waser) for designing the figures. We thank Dr. E. Milner for critical reading of the manuscript. Research in the authors' laboratory is supported by the Medical Research Council of Canada, the Heart and Stroke Foundation of Alberta and the Muscular Dystrophy Association of Canada.
E. Milner for critical reading of the manuscript. Research in the authors' laboratory is supported by the Medical Research Council of Canada, the Heart and Stroke Foundation of Alberta and the Muscular Dystrophy Association of Canada. M. is a Senior Scholar of the Alberta Heritage Foundation for Medical Research and MRC Scientist. B. was a recipient of a studentship from the Heart and Stroke Foundation of Canada. REFERENCES 1. Ostwald TJ, MacLennan DH. Isolation of a high affinity calcium binding protein from sarcoplasmic reticulum.
Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein. EMBO J 1989; 8:3581-6. 13. Treves S, De Mattei M, Landfredi M et al. Calreticulin is a candidate for a calsequestrin-like function in Ca2+-storage compartments (calciosomes) of liver and brain. Biochem J 1990; 271:473-80. The Intracellular Distribution and Expression of Calreticulin 39 14. Krause K-H, Simmerman HKB, Jones LR et al. Sequence similarity of calreticulin with a Ca2+-binding protein that co-purifies with an Ins(l,4,5)Prsensitive Ca2+ store in HL-60 cells.