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Download Carbohydrate-Based Drug Discovery by Chi-Huey Wong PDF

By Chi-Huey Wong

Content material:
Chapter 1 man made Methodologies (pages 1–36): Chikako Saotome and Osamu Kanie
Chapter 2 advanced Carbohydrate Synthesis (pages 37–54): Makoto Kiso, Hideharu Ishida and Hiromune Ando
Chapter three The Chemistry of Sialic Acid (pages 55–102): Geert?Jan Boons and Alexei V. Demchenko
Chapter four Solid?Phase Oligosaccharide Synthesis (pages 103–127): Peter H. Seeberger
Chapter five answer and Polymer?Supported Synthesis of Carbohydrates (pages 129–136): Shin?Ichiro Nishimura
Chapter 6 Enzymatic Synthesis of Oligosaccharides (pages 137–167): Jianbo Zhang, Jun Shao, Prezemk Kowal and Peng George Wang
Chapter 7 Glycopeptides and Glycoproteins: man made Chemistry and Biology (pages 169–214): Oliver Seitz
Chapter eight Synthesis of advanced Carbohydrates: Everninomicin (pages 215–252): okay. C. Nicolaou, Helen J. Mitchell and Scott A. Snyder
Chapter nine Chemical Synthesis of Asparagine?Linked Glycoprotein Oligosaccharides: contemporary Examples (pages 253–280): Yukishige Ito and Ichiro Matsuo
Chapter 10 Chemistry and Biochemistry of Asparagine?Linked Protein Glycosylation (pages 281–303): Barbara Imperiali and Vincent W.?F. Tai
Chapter eleven Conformational research of C?Glycosides and comparable Compounds: Programming Conformational Profiles of C? and O?Glycosides (pages 305–340): Peter G. Goekjian, Alexander Wei and Yoshito Kishi
Chapter 12 man made Lipid A Antagonists for Sepsis therapy (pages 341–355): William J. Christ, Lynn D. Hawkins, Michael D. Lewis and Yoshito Kishi
Chapter thirteen Polysialic Acid Vaccines (pages 357–380): Harold J. Jennings
Chapter 14 artificial Carbohydrate?Based Vaccines (pages 381–406): Stacy J. Keding and Samuel J. Danishefsky
Chapter 15 Chemistry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and similar Saccharides (pages 407–439): Tasneem Islam and Robert J. Linhardt
Chapter sixteen a brand new iteration of Antithrombotics according to man made Oligosaccharides (pages 441–459): Maurice Petitou and Jean?Marc Herbert
Chapter 17 Sequencing of Oligosaccharides and Glycoproteins (pages 461–482): Stuart M. Haslam, Kay?Hooi Khoo and Anne Dell
Chapter 18 coaching of Heterocyclic 2?Deoxystreptamine Aminoglycoside Analogues and Characterization in their interplay with RNAs via Use of Electrospray Ionization Mass Spectrometry (pages 483–499): Richard H. Griffey, Steven A. Hofstadler and Eric E. Swayze
Chapter 19 Glycosylation research of a Recombinant P?Selectin Antagonist via High?pH Anion?Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED) (pages 501–516): Mark R. Hardy and Richard J. Cornell
Chapter 20 Analytical concepts for the Characterization and Sequencing of Glycosaminoglycans (pages 517–539): Ram Sasisekharan, Zachary Shriver, Mallik Sundaram and Ganesh Venkataraman
Chapter 21 Thermodynamic types of the Multivalency influence (pages 541–574): Pavel I. Kitov and David R. Bundle
Chapter 22 man made Multivalent Carbohydrate Ligands as Effectors or Inhibitors of organic techniques (pages 575–608): Laura L. Kiessling, Jason okay. Pontrello and Michael C. Schuster
Chapter 23 Glycosyltransferase Inhibitors (pages 609–659): Karl?Heinz Jung and Richard R. Schmidt
Chapter 24 RNA?Aminoglycoside Interactions (pages 661–683): Haim Weizman and Yitzhak Tor
Chapter 25 Glycosylated usual items (pages 685–711): Jon S. Thorson and Thomas Vogt
Chapter 26 Novel Enzymatic Mechanisms within the Biosynthesis of surprising Sugars (pages 713–745): Alexander Wong, Xuemei He and Hung?Wen Liu
Chapter 27 Neoglycolipids: id of sensible Carbohydrate Epitopes (pages 747–760): Ten Feizi, Alexander M. Lawson and Wengang Chai
Chapter 28 A Preamble to Aglycone Reconstruction for Membrane?Presented Glycolipid Mimics (pages 761–779): Murugesapillai Mylvaganam and Clifford A. Lingwood
Chapter 29 Small Molecule Inhibitors of the Sulfotransferases (pages 781–801): sunrise E. Verdugo, Lars C. Pedersen and Carolyn R. Bertozzi
Chapter 30 Carbohydrate?Based therapy of melanoma Metastasis (pages 803–829): Reiji Kannagi
Chapter 31 N?Acetylneuraminic Acid Derivatives and Mimetics as Anti?Influenza brokers (pages 831–861): Robin Thomson and Mark von Itzstein
Chapter 32 converted and editing Sugars as a brand new device for the advance of healing brokers – The Biochemically Engineered N?Acyl aspect Chain of Sialic Acid: organic Implications and attainable makes use of in drugs (pages 863–873): Rudiger Horstkorte, Oliver T. Keppler and Werner Reutter
Chapter 33 transformed and editing Sugars as a brand new device for the advance of healing brokers – Glycosidated Phospholipids as a brand new kind of Antiproliferative brokers (pages 875–882): Kerstin Danker, Annette Fischer and Werner Reutter
Chapter 34 Glycoside Primers and Inhibitors of Glycosylation (pages 883–898): Jillian R. Brown, Mark M. Fuster and Jeffrey D. Esko
Chapter 35 Carbohydrate?Based Drug Discovery within the conflict opposed to Bacterial Infections: New possibilities coming up from Programmable One?Pot Oligosaccharide Synthesis (pages 899–932): Thomas okay. Ritter and Prof. Dr. Chi?Huey Wong

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Extra resources for Carbohydrate-Based Drug Discovery

Example text

Chem. Soc. 1996, 118, 9998–9999. 1 Introduction Complex carbohydrates on cell surfaces (Fig. 1) have been recognized to play crucial roles in various biological processes such as infection, reception of toxins and hormones, fertilization, cell adhesion, cell differentiation and proliferation, tumor progression, aging, immune responses, brain-neural functions, and so on. The oligosaccharide components, exposed to the external environment as ligands or receptors, code a variety of biological information to regulate the physiological functions.

Danishefsky, S. J. Angew. Chem. Int. Ed. Engl. 1998, 37, 786–787. Danishefsky, S. ; Bilodeau, M. T. Angew. Chem. Int. Ed. Engl. 1996, 35, 1380– 1419. ; Takahashi, T. Tetrahedron Lett. 1999, 40, 2141–2144. ; Meldal, M. Tetrahedron Lett. 1996, 37, 6185–6188. ; Bock, K. J. Am. Chem. Soc. 1999, 121, 5459–5466. ; Piccialli, G. Tetrahedron Lett. 1996, 37, 5007–5010. ; Kahne, D. Proc. Natl. Acad. Sci. USA 1997, 94, 10554–10559. ; Kahne, D. Synlett 1995, 523– 524. ; Yonemitsu, O. Tetrahedron Lett. 1982, 23, 885–888.

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