By Peng-Fei Xu, Wei Wang
Demonstrates the benefits of catalytic cascade reactions for synthesizing common items and pharmaceuticals
Riding the wave of eco-friendly chemistry, catalytic cascade reactions became essentially the most energetic examine components in natural synthesis. in the course of a cascade response, only one response solvent, one workup technique, and one purification step are wanted, therefore considerably expanding man made efficiency.
Featuring contributions from a world workforce of pioneers within the box, Catalytic Cascade Reactions demonstrates the flexibility and alertness of those reactions for synthesizing beneficial compounds. The ebook examines either organocatalysis and transition-metal catalysis reactions, bringing readers brand new with the newest discoveries and actions in all significant components of catalytic cascade response research.
Catalytic Cascade Reactions begins with 3 chapters devoted to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the applying of organocatalytic cascade reactions in average product synthesis and drug discovery. subsequent, the booklet covers:
- Gold-catalyzed cascade reactions
- Cascade reactions catalyzed by means of ruthenium, iron, iridium, rhodium, and copper
- Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes
- Application of transition-metal catalyzed cascade reactions in normal product synthesis and drug discovery
- Engineering mono- and multifunctional nanocatalysts for cascade reactions
- Multiple-catalyst-promoted cascade reactions
All chapters are completely referenced, offering easy access to special unique learn findings and studies in order that readers can discover person themes in larger depth.
Drawing jointly and reading released findings scattered around the literature, this publication offers a unmarried resource that encapsulates our present realizing of catalytic cascade approaches. additionally, it units the level for the improvement of recent catalytic cascade reactions and their functions.
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Extra info for Catalytic Cascade Reactions
85 Catalytic enantioselective hydride-transferring closure. Other iminium-activated cascade reactions, including [4 + 3] cycloaddition, Robinson annulations, and reductive Michael cyclization, were also developed to furnish useful synthons . 4 Cycle-specific catalysis cascades Inspired by the capacity of discrete transform-specific enzymes to coexist in the same reaction medium without unfavorable consequences, Huang et al. hypothesized that the conceptual blueprints of biosynthesis might be translated into a laboratory cascade catalysis sequence through a combination of chiral amine catalysts .
76) . The one-pot organocatalytic domino reactions between γ-chloro-β-keto esters 176 and α,β-unsaturated aldehydes occurred with catalyst 128 and AcONa as additive. 76 Organocatalyzed one-pot Michael–aldol–SN2 cascade. converted into the optically active epoxy cyclohexanone 177 in the presence of K2CO3. 77. The β-keto ester 176 approaches the planar iminium ion from the Re-face due to steric hindrance of the bulky substituents at the chiral substituent in the pyrrolidine ring of catalyst 128.
25 Catalytic cycle for an organocatalytic hetero-Diels–Alder reaction. Inverse-electron-demand hetero-Diels−Alder reaction of enolizable aldehydes with α,β-unsaturated ketophosphonates , o-quinones , α-keto-α,β-unsaturated esters , α,β-unsaturated trifluoromethyl ketones , and o-benzoquinone diimide  was also reported. Encouraged by Jørgensen’s inverse-electron-demand hetero-Diels–Alder reaction of aldehydes and α,β-unsaturated α-keto esters, Han, He, and others envisaged that an unprecedented asymmetric aza-Diels–Alder reaction of N-sulfonyl-1-aza-1,3butadienes and aldehydes might be developed by employing a similar strategy.