Geriatrics

Download Dementia in Clinical Practice (Frontiers of Neurology and by P. Giannakopoulos, P.R. Hof, J. Bogousslavsky PDF

By P. Giannakopoulos, P.R. Hof, J. Bogousslavsky

This e-book summarizes the newest advances in neurobiology, diagnostic methods and therapeutics of the main dementing health problems resembling Alzheimer’s affliction, frontotemporal dementia, Lewy physique sickness, and vascular dementia. In a succinct, sensible and accomplished demeanour, it offers an up-to-date view of the issues prone to be encountered in an everyday perform. every one part is targeted on an incredible kind of dementia and is prepared following an analogous scheme reviewing the pathophysiology of the affliction, its diagnostic demanding situations, its attribute neuroimaging positive aspects, healing interventions and sufferer administration concerns. fending off an overspecialized strategy, the booklet bridges the space among scientific perform, complicated imaging, fresh therapeutics and uncomplicated sciences. hence, it serves as a superb consultant for psychological healthiness pros operating within the box of dementia in addition to basic care physicians and scholars.

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Sample text

In parallel to the PET studies with biomarkers, efforts are made to visualize SP with MRI. In transgenic mice models developing cortical plaques, the MRI technique detects the plaques as areas of low signal [29]. While preliminary results are promising, more data must be acquired before applying the method to MCI and early AD patients. Finally, indirect approaches focus on the detection of changes in serotonin or other neurotransmitter receptors as a result of cell death in hippocampus and entorhinal cortex.

Methodological difficulties should be also considered when interpreting these observations. From a strictly technical point of view, the first period of clinicopathological correlations in AD were based on lesion densities that are subject to major sampling biases. For instance, estimates of synaptic loss relied upon density measures and nonsystematic sampling based on two unwarranted assumptions, namely that the size of the region under analysis remains constant across diagnostic groups and that synaptic size does not change [23].

Neurology 1989;39:1427–1434. Neuroimaging in MCI 15 Herholz K: FDG PET and differential diagnosis of dementia. Alzheimer Dis Assoc Disord 1995;9:6–16. 16 Ibanez V, Pietrini P, Alexander GE, Furey ML, Teichberg D, Rajapakse JC, Rapoport SI, Schapiro MB, Horwitz B: Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer’s disease. Neurology 1998;50:1585–1593. 17 Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D: Preclinical evidence of Alzheimer’s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

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