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By Roy Jones

St. Martin's health center, bathtub, united kingdom.

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In addition it needs to be taken frequently and this is another limitation in predominantly elderly patients with memory problems. In general, tacrine has been displaced by its successors, donepezil and rivastigmine. Availability An aminoacridine compound, it became widely used in many countries including the USA, Sweden and France but has never been marketed in the UK. Donepezil (Aricept; EisaVPfizer) The year of 1997 saw the approval of donepezil, the first drug to be marketed in the UK for the symptomatic treatment of mild or moderate dementia in AD.

E. as a group their cognitive function was improved for this time). 6 points per year, comparable with that previously reported for untreated patients. This suggests a continued treatment effect with long-term therapy that is also confirmed by more general clinical use [ 101. Anecdotally, some patients clearly show an improvement that is more remarkable and sustained than the group data might suggest. This is not surprising and illustrates the danger of basing all judgements about a therapy on mean data and forgetting about the individual patient.

Psychopharmacol Bull 1988; 24: 653-9. 20 Reisberg B, Borenstein J, Salob SP, Ferris SH, Franssen E, Georgotas A. Behavioural symptoms in Alzheimer’s disease: phenomenology and treatment. JClin Psychiatry 1987; 48 (Suppl. 5): 9-15. 21 Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-14. 22 Kitwood T. Dementia Reconsidered: the Person Comes First. Buckingham: Open University Press, 1997.

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