By Dan Silverman
Between all of the medical symptoms for which radiologists, nuclear medication phy- cians, neurologists, neurosurgeons, psychiatrists (and others interpreting issues of the mind) order and browse mind puppy scans, call for is maximum for these concerning dementia and similar problems. This call for is pushed via the sheer occurrence of these stipulations, coupled with the truth that the differential prognosis for motives of cognitive impairment is vast and sometimes tricky to tell apart clinically. The conceptual framework in which evaluate and administration of dementia is guided has advanced significantly over the past decade. even if we nonetheless are faraway from having perfect checks or dramatic treatments for any of the tested explanations of dementia, our recommendations have elevated with appreciate to either the diagnostic and the- peutic instruments now to be had. within the first bankruptcy of this publication, the contribution and barriers of other components of the scientific exam for prognosis of cog- tive signs are defined, and the jobs of structural and sensible neuroim- ing within the scientific workup are given context.
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Extra info for PET in the Evaluation of Alzheimer’s Disease and Related Disorders
Progressive changes observed with PET in the brains of patients who experience very mild symptoms, to those who meet criteria for having mild cognitive impairment, to those suffering from full-blown dementia, are described, as is the role of PET in the differential diagnosis of the underlying cause for the dysfunction. Neurodegenerative diseases often impact not only on cognitive function, but also on motor function. The two neurologic domains can be affected in isolation, but frequently a mixed presentation of symptoms occurs.
SilvermanDavid Geffen School of Medicine, University of California, Los Angeles, CA, USA ISBN 978-0-387-76419-1e-ISBN 978-0-387-76420-7 Library of Congress Control Number: 2008940848 � Springer-Verlag New York 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science + Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis.
Following the introduction of this area of investigation in the fifth chapter, Chapter 6 is devoted to expanding on the scientific implications and clinical potential of radiotracers being developed to localize and measure β-amyloid deposits occurring in the brain. In the latter chapter, particular attention is given to characterizing β-amyloid deposition in older people who would not be considered cognitively impaired by standard clinical criteria. PET scans, particularly with FDG, have demonstrated diagnostic and prognostic utility in evaluating patients with cognitive impairment and in distinguishing among primary neurodegenerative disorders and other etiologies for cognitive decline.